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Global sensitivity analysis of absorption, distribution, metabolism, and excretion parameters of edoxaban and M4 on AUC of edoxaban (a), area under the curve (AUC) of M4 (b) and AUC of anticoagulation pharmacodynamic response (c). μ*: The average of absolute elementary effects. CLint, intrinsic clearance; J max, maximal flux value; Peff, effective permeability.
