TABLE 1.
Frequency of alleles that affect the metabolic phenotype of CYP2C19.
| MP | GT | Frequencies | |||
|---|---|---|---|---|---|
| Western | Japanese | ||||
| GT | MP | GT | MP | ||
| EM | *1*17 | 0.3239 | 0.7319 | 0.0100 | 0.3200 |
| *17*17 | 0.0070 | – | |||
| *1*1 | 0.4010 | 0.3100 | |||
| IM | *1*2 | 0.1972 | 0.2535 | 0.3900 | 0.4900 |
| *2*17 | 0.0563 | – | |||
| *3*17 | – | – | |||
| *1*3 | – | 0.1000 | |||
| PM | *2*2 | 0.0141 | 0.0141 | 0.1300 | 0.1900 |
| *2*3 | – | 0.0400 | |||
| *3*3 | – | 0.0200 | |||
Note: CYP2C19 is well‐known for its various genotypes that affect each MP. This study concentrated on the major genotypes that are known to exist in Japanese and Whites, and their frequencies were used for calculations of oral clearance for CYP2C19, as mentioned in the Materials and Methods.
Abbreviations: EM, extensive metabolizer; GT, genotype; IM, intermediate metabolizer; MP, metabolic phenotype; PM, poor metabolizer.
The information is derived from Myrand et al. 29