Skip to main content
. Author manuscript; available in PMC: 2023 Aug 16.
Published in final edited form as: Mucosal Immunol. 2023 Mar 2;16(3):233–249. doi: 10.1016/j.mucimm.2023.02.006

Fig. 4.

Fig. 4

IL-10R-deficient hematopoietic cells confer an inflammatory phenotype on WT colonic macrophages. (A) Experiment scheme of generated bone marrow chimeras. Cdcs1 (CD45.1) (WT) hosts were reconstituted with either WT or Cdcs1 Il10ra−/− (Il10ra−/−) bone marrow or a 1:1 mixture of both (Mix); (B) percentages of LP macrophages of indicated genotypes in chimeric mice after the induction of colitis (WTmix and Il10ra−/−mix indicates that cells were isolated from mixed chimeras); (C) histopathologic scores; (D) representative flow cytometry showing macrophage subsets in the colon. Cdcs1 WT (CD45.1) and Cdcs1 Il10ra−/− (CD45.2); (E) percentages of each macrophage (MΦ) subset as a proportion of total macrophages of the indicated genotype. Results are pooled from two independent experiments and median values are shown. * p < 0.05 Mann-Whitney U test. IL = interleukin; LP = lamina propria; WT = wild-type.