TABLE 2.

Population statistics split by asthma severity, and all subjects combined. Quantitative measures are presented as median [1st quartile—3rd quartile]. Whole lung mucus score presented is the sum of all segmental mucus scores. Measures are acquired after administration of four puffs of bronchodilator. All statistics were calculated using the Wilcoxon Rank Sum test with a significance threshold of p < 0.05. PP, percent predicted.

	Healthy	Mild/Moderate asthmatics	Severe asthmatics	All
N	4	13	21	38
Gender	1M:3F	5 M: 8F	8M: 13F	14M:24F
Age (years)	38.5 [26.6—52.2]	49.5 [36.8—53.3]	56.1 [47.1—62.6]	51.2 [45.6—61.0]
High Dose ICS	N/A	3	21	24
Daily OCS Dependent (Dose)	N/A	0	3 (4, 7, 8 mg)	3
Monoclonal Rx	N/A	1	4	5
BMI	25.4 ^ [24.0–27.0]	27.7 † [24.7—29.0]	32.4 ^† [282—34.5]	29.0 [26.3—34.1]
FEV1 PP	111 ^ [106—166]	87.8† [83.0—94.6]	77.8% ^† [69.1—97.7]	86.5% [75.4—105]
FVC PP	109 ^ [101—118]	101 † [86.6—109]	86.7 ^† [82.9—97.2]	93.6% [84.8—105]
FEV1/FVC PP	102 ^ [99.0—104]	96.2 [89.1—99.1]	91.1 ^ [82.3—98.5]	96.1% [85.5—99.0]
FEF25-75 PP	118 *^ [113—121]	79.5* [61.8—95.2]	55.8 ^ [38.7—90.8]	78.0 [51.1—105]
VDP	0.275% *^ [0.0750—0.629]	2.51% *† [1.17—4.30]	6.18% ^† [3.40—11.4]	3.43% [2.05—6.97]
fSAD	0.122% [0.0554–1.55]	0.620% [0.406—3.86]	1.36% [0.481—5.77]	1.19% [0.280—5.18]
Emph	0.0571% [0.0447—0.0816]	0.0875% [0.0613—0.124]	0.676% [0.0409—0.154]	0.0673% [0.0472—0.135]
Whole lung Mucus Score	0.0 [0.0—0.0]	0.0 [0.0—0.25]	0.0 [0.0—4.0]	0.0 [0.0—1.6]

*Significantly different between Healthy and Mild/Moderate Asthmatics.

^Significantly different between Healthy and Severe Asthmatics.

^†Significantly Different between Mild/Moderate and Severe Asthmatics.