Table 2. ADME Prediction of Oxadiazole Analogues (6a–j).
| s. no. | compound | % ABS | volume | TPSA | NROTB | HBA | HBD | Log P (iLOGP) | MW | BBB permeation | GI absorption | Lipinski’s violations |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 6a | 91.42 | 232.24 | 50.95 | 3 | 7 | 1 | 2.73 | 309.22 | yes | high | 0 |
| 2 | 6b | 91.42 | 240.85 | 50.95 | 3 | 6 | 1 | 2.90 | 325.67 | no | high | 0 |
| 3 | 6c | 91.42 | 245.20 | 50.95 | 3 | 6 | 1 | 2.99 | 370.12 | no | high | 0 |
| 4 | 6d | 91.42 | 243.87 | 50.95 | 3 | 6 | 1 | 2.88 | 305.25 | yes | high | 0 |
| 5 | 6e | 88.24 | 252.86 | 60.18 | 4 | 7 | 1 | 2.93 | 321.25 | yes | high | 0 |
| 6 | 6f | 91.42 | 240.85 | 50.95 | 3 | 6 | 1 | 3.01 | 325.67 | no | high | 0 |
| 7 | 6g | 88.24 | 252.86 | 60.18 | 4 | 7 | 1 | 3.11 | 321.25 | yes | high | 0 |
| 8 | 6h | 91.42 | 260.43 | 50.95 | 3 | 6 | 1 | 3.23 | 319.28 | yes | high | 0 |
| 9 | 6i | 91.42 | 260.43 | 50.95 | 3 | 6 | 1 | 3.23 | 319.28 | yes | high | 0 |
| 10 | 6j | 91.42 | 245.78 | 50.95 | 3 | 7 | 1 | 2.85 | 343.66 | no | high | 0 |