Table 4. Comparative Anticancer Activity of Oxadiazole Analogues (6a–j) on the Percent of Growth Inhibitions (% GIs) Scalea.
| cell
line (percent of growth inhibition; % GI) |
|||
|---|---|---|---|
| compounds | >68 | 67.99 to 50.00 | 49.99 to 20.00 |
| 6a | - | - | - |
| 6b | - | - | NCI-H460 (23.62) |
| 6c | - | - | UO-31 (20.89) |
| 6d | MCF7 (81.94) | HCT-116 (64.47) | K-562 (47.25) |
| HT29 (47.22) | |||
| IGROV1 (46.1) | |||
| UO-31 (31.48) | |||
| COLO 205 (28.33) | |||
| PC-3 (27.62) | |||
| T-47D (27.43) | |||
| HCT-15 (26.97) | |||
| MALME-3M (20.75) | |||
| 6e | - | - | - |
| 6f | - | HCT-116 (67.16) | HCT-15 (43.79) |
| MCF7 (57.14) | CAKI-1 (36.5) | ||
| MOLT-4 (32.94) | |||
| K-562 (32.31) | |||
| RPMI-8226 (28.92) | |||
| COLO 205 (26.41) | |||
| NCI-H522 (25.68) | |||
| UO-31 (25.32) | |||
| MDA-MB-468 (24.38) | |||
| UACC-62 (22.87) | |||
| CCRF-CEM (22.46) | |||
| HT29 (22) | |||
| PC-3 (20.76) | |||
| 6g | - | - | UACC-62 (25.52) |
| MOLT-4 (25.26) | |||
| HCT-116 (24.32) | |||
| HCT-15 (20.46) | |||
| 6h | SNB-19 (86.61) | HOP-62 (67.55) | U251 (49.65) |
| OVCAR-8 (85.26) | SNB-75 (65.46) | NCI-H226 (49.55) | |
| NCI-H460 (75.99) | ACHN (59.09) | HS 578T (48.22) | |
| NCI/ADR-RES (59.02) | OVCAR-4 (48.19) | ||
| 786-O (57.88) | SF-268 (48.16) | ||
| A549/ATCC (56.88) | NCI-H322M (45.92) | ||
| HCT-116 (56.53) | RXF 393 (44.96) | ||
| MDA-MB-231 (56.4) | CAKI-1 (41.91) | ||
| SF-295 (51.88) | SK-OV-3 (41.46) | ||
| UO-31 (40.82) | |||
| SF-539 (35.31) | |||
| NCI-H522 (30.22) | |||
| SN12C (28.43) | |||
| NCI-H23 (25.81) | |||
| PC-3 (23.09) | |||
| HOP-92 (22.86) | |||
| DU-145 (22.13) | |||
| IGROV1 (21.44) | |||
| EKXVA (21.2) | |||
| OVCAR-3 (21.18) | |||
| SK-MEL-28 (21.05) | |||
| 6i | MCF7 (85.39) | K-562 (51.8) | HT29 (41.01) |
| HCT-116 (71.08) | HCT-15 (38.76) | ||
| PC-3 (37.29) | |||
| UO-31 (31.3) | |||
| IGROV1 (30.87) | |||
| COLO 205 (30.81) | |||
| T-47D (28.84) | |||
| RPMI-8226 (26.8) | |||
| MOLT-4 (26.23) | |||
| NCI-H23 (24.23) | |||
| MALME-3M (22.98) | |||
| CCRF-CEM (20.24) | |||
| 6j | - | - | MCF7 (23.11) |
| UO-31 (22.03) | |||
a
(-) None of the cell lines displayed a growth inhibition of this percentage.