FIG. 4.

Relationship between OHV with HBV isolated from humans and hepadnaviruses isolated from chimpanzees, gibbons, and woolly monkeys (Woolly). The tree represents an unrooted consensus tree obtained by the neighbor-joining method based on the nucleotide sequence of the small S protein. Bootstrap analysis was applied using 100 values. Values on the branches represent the percentage of trees for which the sequences at one end of the branch are a monophyletic group. The OHV clade as well as the different HBV genotypes and their geographic origins are indicated. The human HBV isolates are identified by their GenBank database accession numbers. Accession numbers for chimpanzee and gibbon HBV are described elsewhere. The accession number of the woolly monkey hepadnavirus is AF046996. Sequence data of OHV isolates described in this article are deposited in the EMBL and GenBank data libraries.