Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 15;20(1):588–602. doi: 10.1080/15476286.2023.2244791

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

PMC Copyright notice

Figure 1. — Protein-responsive OFF-type translational regulators.

(A) Aptamers are RNA elements that can interact with specific ligands. In protein-responsive mRNA switches, aptamers that interact with RNA-binding proteins (RBPs) are inserted into the 5’-UTR of mRNAs (left). In the absence of the target RBP, L7Ae, an mRNA harbouring the BoxC/D motif (L7Ae aptamer) is translated, while the L7Ae−BoxC/D interaction represses the translation (right). CDS: coding sequence. (B) A drug-dependent translation regulator using the drug-inducible stabilization of L7Ae. TMP: trimethoprim. DD: destabilization domain. (C) An L7Ae-based protein sensor. TEVp: TEV protease. CS: cleavage site of TEVp. scFv: single-chain variable fragment.