Table 3.

Effect on clinical variables of the cortical thickness (CT) of temporal structures in SCN1A-related epilepsy patients. Data were analyzed by a multivariate linear regression model () to explore the effect on the clinical variables of patients because of the center of acquisition (), group (), and age (Age).

		Age at seizure onset		pSCN1A		Clinical diagnosis (DS vs GEFS+)
Region	Side		P value		P value		P value
Entorhinal	L	−0.292	0.1563	0.0109	0.174	−0.0307	0.405
	R	−0.360	0.0943	0.0141	0.098	−0.0189	0.614
Fusiform	L	−0.324	0.1929	0.0090	0.309	−0.0785	0.088
	R	−0.462	0.0574	0.0147	0.120	−0.0329	0.507
Parahippocampal	L	−0.264	0.1914	0.0130	0.114	−0.0356	0.226
	R	−0.293	0.1566	0.0136	0.096	−0.0613	0.030
Superior temporal	L	−0.400	0.0552	0.0172	0.039	−0.0218	0.545
	R	−0.409	0.0543	0.0197	0.024	−0.0169	0.650
Middle temporal	L	−0.418	0.0570	0.0157	0.067	−0.0367	0.380
	R	−0.392	0.0577	0.0170	0.045	−0.0251	0.515
Inferior temporal	L	−0.429	0.0409	0.0173	0.042	−0.0305	0.416
	R	−0.413	0.0536	0.0160	0.064	−0.0340	0.393
Temporal pole	L	−0.411	0.0485	0.0161	0.062	−0.0192	0.614
	R	−0.419	0.0390	0.0171	0.030	−0.0199	0.611
Frontal pole	L	−0.440	0.08459	0.0167	0.107	−0.0464	0.409
	R	−0.632	0.0112	0.0200	0.056	−0.0571	0.340
Insula	L	−0.364	0.11663	0.0141	0.130	−0.0368	0.355
	R	−0.362	0.0775	0.0147	0.064	−0.0230	0.519
Mean thickness	L	−0.432	0.06522	0.0143	0.109	−0.0473	0.332
	R	−0.477	0.0353	0.0160	0.075	−0.0335	0.494

Bold indicates significantly altered measures (P < 0.05).