Comparison 3. Prophylactic antipsychotic versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incident delirium	3	916	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.33, 1.59]
1.1 Haloperidol	2	516	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.69, 1.60]
1.2 Olanzapine	1	400	Risk Ratio (M‐H, Random, 95% CI)	0.36 [0.24, 0.52]
2 Duration of delirium	2	178	Mean Difference (IV, Random, 95% CI)	‐2.74 [‐9.59, 4.11]
2.1 Haloperidol	1	68	Mean Difference (IV, Random, 95% CI)	‐6.4 [‐9.38, ‐3.42]
2.2 Olanzapine	1	110	Mean Difference (IV, Random, 95% CI)	0.60 [0.10, 1.10]
3 Severity of delirium	2	178	Mean Difference (IV, Random, 95% CI)	‐1.02 [‐6.80, 4.76]
3.1 Haloperidol	1	68	Mean Difference (IV, Random, 95% CI)	‐2.00 [‐5.86, ‐2.14]
3.2 Olanzapine	1	110	Mean Difference (IV, Random, 95% CI)	1.90 [0.41, 3.39]
4 Length of admission	1	68	Mean Difference (IV, Random, 95% CI)	‐5.5 [‐12.17, 1.17]
4.1 Haloperidol	1	68	Mean Difference (IV, Random, 95% CI)	‐5.5 [‐12.17, 1.17]
5 Cognition	1	110	Mean Difference (IV, Random, 95% CI)	‐4.90 [‐7.42, ‐2.38]
6 Withdrawal from protocol	2	925	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.68, 1.24]
6.1 Haloperidol	1	430	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.43, 1.26]
6.2 Olanzapine	1	495	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.71, 1.46]
7 Adverse events	1	430	Risk Ratio (M‐H, Random, 95% CI)	0.39 [0.10, 1.43]
7.1 Haloperidol	1	430	Risk Ratio (M‐H, Random, 95% CI)	0.39 [0.10, 1.43]
8 Pneumonia	1	400	Risk Ratio (M‐H, Random, 95% CI)	7.28 [0.38, 140.11]
9 Urinary tract infection	1	400	Risk Ratio (M‐H, Random, 95% CI)	0.26 [0.03, 2.31]
10 Congestive heart failure	1	400	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.07, 16.52]