Brzezinski 2012.

Trial name or title	Effect of prophylactic, perioperative propranolol on peri‐ and postoperative complications in patients With Post Traumatic Stress Disorder
Methods	Randomised double‐blind placebo‐controlled trial
Participants	Patients over 40 with full or subthreshold PTSD of three months duration admitted for any surgical procedure (except open‐heart or intracranial surgery) requiring general or combined general‐regional anaesthesia and an overnight hospital stay.
Interventions	Experimental: Drug: Propranolol hydrochloride will be taken for a total of 14 days commencing on the morning of surgery Comparator: Placebo pill will be taken for a total of 14 days commencing on the morning of surgery
Outcomes	Primary outcomes: Postoperative delirium (assessed using CAM, CAM‐ICU), ICU length of stay, hospital length of stay, postoperative renal dysfunction Secondary outcomes: peri‐ and postoperative complications, pain intensity, PTSD symptoms, use of analgesics, length of mechanical ventilation, quality of life, functional status, sleep quality, depression symptoms, postoperative neurocognitive dysfunction score, mortality
Starting date	May 2012
Contact information	brzezinm@anesthesia.ucsf.edu curt.johanson@va.gov
Notes	ClinicalTrials.gov identifier: NCT01555554 Estimated primary completion date December 2013