Nanayakkara 2011.

Trial name or title	Early pharmacological intervention to prevent delirium: Haloperidol prophylaxis in older emergency department patients
Methods	Multi‐centre double‐blind randomised placebo‐controlled trial
Participants	Patients aged 70 or over, admitted to a medical or surgical specialty and at risk of delirium according to one or more positive answers on the VMS delirium‐risk questions
Interventions	Intervention: Haloperidol 1 mg twice daily at 12 am and 8 pm, orally Control: Placebo 1 mg twice‐daily at 12 am and 8 pm, orally
Outcomes	Primary outcome: Incident delirium and delirium duration (measured with Delirium Observation Screening (DOS) score) Secondary outcome Measures: Time to develop delirium, length of stay, ; The (mean) number of days participants are admitted to the hospital; change from baseline function at 3 and 6 months (ADL scale), change from baseline instrumental activities at 3 and 6 months (Instrumental ADL scale); mortality.
Starting date	November 2012
Contact information	p.nanayakkara@vumc.nl
Notes	ClinicalTrials.gov identifier: NCT01530308 Estimated primary completion date April 2014