Silverstein 2008.

Trial name or title	Perioperative cognitive function ‐ dexmedetomidine and cognitive reserve
Methods	Multi‐centre double‐blind randomised placebo‐controlled trial
Participants	68 years and older, undergoing elective major surgery under general anaesthesia, ASA grade I‐III, MMSE >20
Interventions	Intervention: Precedex (dexmedetomidine). 0.5/ug/kg/hr. Dexmedetomidine infusions will begin prior to the surgery (no loading dose), and will be maintained at 0.5 mcg/kg/hour throughout surgery and titrated postoperatively for 2 hrs postoperatively. Control: Placebo infusion.
Outcomes	Primary outcome: Delirium Battery post‐surgery and then daily for 5 days then at 3 and 6 months Secondary outcomes: Neuropsychological testing at 3 and 6 months
Starting date	February 2008
Contact information	Jeff Silverstein, Mount Sinai School of Medicine jeff.silverstein@mountsinai.org
Notes	ClinicalTrials.gov identifier: NCT00561678 Estimated Primary Completion Date: June 2013