Table 1.
A summary of the key findings of each Original article published in this Research Topic.
| Article | Highlights | Type |
|---|---|---|
| Fröhlich et al. | 1. Designed and tested a dual-function AAV vector that increased ASPA expression whilst lowering Nat8l expression in in vitro and in vivo experimental settings. 2. Post-symptomatic treatment robustly improved disease phenotypes of aged Canavan diseased mice. 3. Concluded that using such dual-function vectors can create a bigger therapeutic window for Canavan disease, and has implications for other leukodystrophies. |
Original research |
| Liu and Rask-Andersen | 1. Performed an RNAscope® analyses to spatially localize targeted mRNAs in specific human cochlea regions. 2. Visualized single gene transcripts in the human cochlea using super-resolution structured illumination microscopy (SR-SIM). 3. Identified that most Na/K-ATPase gene transcripts were localized in specialized areas of the cochlear wall epithelium, fibrocyte networks, and spiral ganglions to confirm their essential role in human cochlear function. |
Original research |
| Surdyka et al. | 1. Compared the transduction efficiencies of AAV-PHP.eB and AAVrh10 in the cerebellum. 2. Revealed that CMV and PGK promoters induced comparable transduction levels in Purkinje and granule cells. 3. Demonstrated that the location of injections (i.e., deep cerebellar nuclei vs lobular injections) induced different patterns of transduction of cerebellar neurons. |
Original research |
| Arizaca Maquera et al. | 1. Analyzed the transcriptome of the entorhinal and temporal cortices during progression of Alzheimer's disease (AD) using human postmortem samples from patients with Braak stages I–VI. 2. Indicated that during disease progression circRNAs could act on the protein level after their translation is activated through A > I RNA editing. 3. Proposed a novel role of circular RNAs in AD. |
Original research |
| Baker et al. | 1. Examined the effects of paclitaxel (PTX) on the voltage-gated sodium channel NaV1.8 in dorsal root ganglion (DRG) neurons cultured in microfluidic chambers. 2. Using Optical Pulse-chase Axonal Long-distance microscopy, PTX treatment elevated NaV1.8 levels in DRG axon tips, and enhanced flux of NaV1.8 containing vesicles. 3. Highlighted the importance of subcellular localization of ion channels in DRG neurons in the context of chemotherapy induced peripheral neuropathy. |
Original research |
| Li et al. | 1. Established an experimental rat model of Parkinson's Disease (PD) using Rotenone-induced lesions to the striatum. 2. Applied next generation sequencing (NGS) to characterize the expression profile of striatal miRNAs in control and PD-induced rats. 3. Identified therapeutic targets by evaluating the miRNA profiles of extracellular vesicles from midbrain regions of control and PD-rats. |
Original research |