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Tumor weight in mice immunized with BC219, BC219-E7, BC219-E7 mutant DNA vaccine. Two weeks after the immunization, mice (10 mice per group) were challenged with 2.5 × 104 RMA-E7 cells. The data represent the weight of individual tumors measured at the end of week 4 after tumor challenge. The median of the weight is shown by bars. The tumor weight from the mice immunized with BC219-E7 is significantly less than that from the mice immunized with BC219 (P < 0.01).
