Table 2.
hTERT promoter mutation in hepatocellular carcinoma (HCC): general data and association with clinical and pathomorphological findings.
| Number of cases with cirrhosis (absolute numbers and %) | Number of cases without cirrhosis (absolute numbers and %) | Total number (%) | Comparative test | p | ||
|---|---|---|---|---|---|---|
| 1 | Frequency of cirrhosis | 93 (58.1) | 67 (41.9) | 160 | ||
| 2 | hTERT promoter mutation | 71 (70.3) | 30 (29.7) | 101 (63.1) | 2 vs. 3 | <0.00∗ |
| 3 | Wildtype hTERT | 22 (37.3) | 37 (62.7) | 59 (36.9) | ||
| 4 | Males with hTERT promoter mutation | 61 (73.5) | 22 (26.5) | 83 (63.4) | ||
| 5 | Females with hTERT promoter mutation | 10 (55.6) | 8 (44.4) | 18 (62.1) | ||
| 6 | Patients < 60 years with hTERT promoter mutation | 14 (56.0) | 3 (25.0) | 17 (45.9) | 6 vs. 7 | 0.01∗ |
| 7 | Patients > 60 years with hTERT promoter mutation | 57 (83.3) | 27 (49.1) | 84 (68.3) | ||
| 8 | Alcoholic liver disease | 31 (71.5) | 13 (29.5) | 44 (27.5) | ||
| 9 | Hepatitis C virus infection | 17 (73.9) | 6 (26.1) | 23 (14.3) | ||
| 10 | Hepatitis B virus infection | 14 (76.5) | 5 (50.0) | 19 (11.9) | ||
| 11 | G1 HCC with hTERT promoter mutation | 6 (50.0) | 4 (50.0) | 10 (50.0) | 11 vs. 13 cirrhosis | 0.02∗∗ |
| 12 | G2 HCC with hTERT promoter mutation | 48 (76.2) | 22 (45.8) | 70 (63.1) | ||
| 13 | G3 HCC with hTERT promoter mutation | 17 (94.4) | 4 (36.4) | 21 (72.4) | ||
| 14 | Conventional type with hTERT promoter mutation | 62 (75.6) | 12 (50.0) | 84 (71.2) | ||
| 15 | Solid type with hTERT promoter mutation | 3 (100) | 10 (62.5) | 13 (68.4) | ||
| 16 | Steatohepatitic type with hTERT promoter mutation | 5 (88.3) | 5 (50.0) | 10 (62.5) | ||
| 17 | Tumor size (cm); hTERT promoter mutation (cm) | 3.9 cm | 6.2 cm | 17 cirrhosis vs. non-cirrhosis | 0.01∗ | |
| 18 | Tumor size (cm) wildtype (cm) | 3.9 cm | 7.7 cm | 18 cirrhosis vs. non-cirrhosis | <0.00∗ |
∗Chi square test. ∗∗Fisher's exact test.