Table 2.

Number of P/LP variants detected per gene in HOP

Gene	Number of P/LP variants
CHEK2	221
ATM	78
MITF	70
BRCA2	55
APC	52
BRCA1	44
BRIP1	33
PMS2	28
PALB2	26
MSH6	20
RET	11
MUTYH	8
NBN	8
RAD51C	8
RAD51D	5
CDKN2A	4
MSH2	3
CDH1	2
MLH1	2
PTEN	2
TSC2	2
SMAD4	1
TP53	1
BAP1	0
BMPR1A	0
CDK4	0
MEN1	0
POLD1	0
RB1	0
STK11	0
TSC1	0
LDLR	46

P/LP, pathogenic or likely pathogenic