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. 2023 Jul 10;110(8):1304–1318. doi: 10.1016/j.ajhg.2023.06.010

Figure 5.

Figure 5

Regional association plots of the highlighted colocalizing regions between type 2 diabetes and osteoarthritis

(A–D) FTO and IRX3 region; (B) TCF7L2 region; (C) WSCD2 and TMEM119 region; (D) TMEM176A region. The plots are colored on the basis of linkage disequilibrium between the lead causal variant of the colocalization and all other variants in the region. The red dashed line represents the genome-wide significance threshold (p value = 5 × 10−8), and the blue dashed line represents a suggestive association threshold (p value = 10−6). PP4 = posterior probability of a single shared causal variant; OA = osteoarthritis; T2D = type 2 diabetes; all OA = osteoarthritis at any site.