Extended Data Fig. 4. ODR-3, LIM-4, tyramine synthesis, and CEPsh glia are not required for UPR^ER activation by 1-undecene odor.

a, Chemotaxis index of N2 and odr-3(rms31) animals following exposure to 1-undecene. n = 15 biological repeats per group, 60 animals per replicate (N2 data displayed is the same as Extended Data Fig. S1b as they were performed at the same time). Graphs show mean CI ± s.d. ****P < 0.0001 (two-tailed unpaired Student’s t test). b, c, d, e Representative fluorescence microscopy images and quantification of hsp-4p::GFP fluorescence in animals with b, odr-3(rms31), c, lim-4(ky403) d, tdc-1(n3419), and e, nsIs180[hlh-17p::recCaspase-3, unc-122p::GFP] backgrounds with or without exposure to 1-undecene for 12 hours. Experiments were repeated three (b, c, e) or four (d) times. n = 30, 32 animals in b, n = 42, 37 animals in c, n = 32, 18 animals in d, n = 11, 10 animals in e. Scale bars, 200 μm. Graphs show mean ± s.d. *P < 0.05, **P < 0.01, ****P < 0.0001 (two-tailed unpaired Student’s t test). Source Data contains precise P values.

Source data