Table 3.
ROC curve analyses of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, circ-RHOT1 and CEA.
| AUC | P | 95% CI | Cut off | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|
| CRC patients from control | ||||||||
| Circ-SMARCA5 | 0.611 | 0.149 | 0.477–0.745 | |||||
| Circ-NOL10 | 0.803 | < 0.001* | 0.702–0.904 | > 1.678# | 70.0 | 95.0 | 97.2 | 55.9 |
| Circ-LDLRAD3 | 0.768 | 0.001* | 0.659–0.876 | > 2.312# | 64.00 | 95.00 | 97.0 | 51.4 |
| Circ-RHOT1 | 0.836 | < 0.001* | 0.744–0.928 | > 2.5847 | 70.0 | 95.0 | 97.2 | 55.9 |
| CEA | 0.878 | < 0.001* | 0.796–0.959 | > 3.7 | 76.0 | 95.0 | 97.4 | 61.3 |
| UC patients from CRC | ||||||||
| Circ-SMARCA5 | 0.782 | 0.005* | 0.655–0.909 | ≤ 0.647# | 90.0 | 70.0 | 37.5 | 97.2 |
| Circ-NOL10 | 0.568 | 0.500 | 0.381–0.755 | |||||
| Circ-LDLRAD3 | 0.560 | 0.552 | 0.406–0.714 | |||||
| Circ-RHOT1 | 0.558 | 0.565 | 0.401 | 0.715 | ||||
| CEA | 0.767 | 0.008* | 0.606–0.928 | ≤ 5# | 90.0 | 64.0 | 33.3 | 97.0 |
| Polyp patients from CRC | ||||||||
| Circ-SMARCA5 | 0.648 | 0.142 | 0.465–0.831 | |||||
| Circ-NOL10 | 0.618 | 0.242 | 0.478–0.758 | |||||
| Circ-LDLRAD3 | 0.540 | 0.692 | 0.354–0.726 | |||||
| Circ-RHOT1 | 0.506 | 0.953 | 0.329–0.683 | |||||
| CEA | 0.729 | 0.023* | 0.576–0.882 | ≤ 6# | 90.0 | 52.0 | 27.3 | 96.3 |
| Piles patients from CRC | ||||||||
| Circ-SMARCA5 | 0.904 | < 0.001* | 0.783–1.000 | ≤ 0.28# | 90.0 | 82.0 | 50.0 | 97.6 |
| Circ-NOL10 | 0.676 | 0.081 | 0.539–0.813 | |||||
| Circ-LDLRAD3 | 0.602 | 0.312 | 0.469–0.735 | |||||
| Circ-RHOT1 | 0.731 | 0.022* | 0.597–0.865 | ≤ 5.28# | 90.0 | 60.0 | 31.0 | 96.8 |
| CEA | 0.795 | 0.003* | 0.676–0.914 | ≤ 4.91# | 90.0 | 64.0 | 33.3 | 97.0 |
AUC, Area under the curve; P value, probability value; CI, confidence intervals; NPV, negative predictive value; PPV, positive predictive value.
*Statistically significant at P ≤ 0.05.
#Cut off was choosing according to Youden index.