Fig. 4. Epigenetic signature of RAD.

Differentially expressed open chromatin region (OCR) across three brain regions and predicted for six cell types. a Cell type-specific OCR between RAD and ADD/NC were mainly found in HIPP (93%) and distributed between microglia (28%), and neuron cells (55%) (multi-testing adjusted two-sided Wilcoxon’s test P values < 0.05, logFC > 0.5). b OCR differentially regulated in RAD in the HIPP was mainly neuron-specific (excitatory specific or shared between inhibitory and excitatory neurons) or microglia-specific. c Number of differentially upregulated and downregulated OCR in RAD per cell type. d GO enrichment applied to RAD-specific OCR (FDR 5%). e Hippocampal RAD-specific OCR intersected with predicted enhancers using the ABC model⁴⁷. Only 50% of RAD-specific OCR were identified as enhancers in HIPP.