Table 4.
Novel PUFA-associated signals (credible sets) from analysis of HIS with external cross-ancestry replication or multi-ancestry validation evidence.
| Traits | Variants (chr:pos:effect:other) | Discovery | Replication | Validation | Direction | Nearest Gene |
|---|---|---|---|---|---|---|
| AA | rs518804 (11:57494487:C:A) | HIS: P = 1.01E−14 | NS |
HDL: P = 1.96E−06 logTG: P = 0.001 |
HIS: (−) HDL: (−) logTG: (+) |
TMX2 |
| rs198434 (11:61483417:A:G) | HIS: P = 2.80E−19 | NS | logTG: P = 1.65E−03 |
HIS: (−) logTG: (+) |
DAGLA | |
| DGLA | rs198461 (11:61524366:C:A) | HIS: P = 2.54E−09 | EUR: P = 7.37E−09 |
HDL: P = 4.81E−13 LDL: P = 1.92E−13 logTG: P = 1.19E−18 TC: P = 5.63E−14 |
HIS: (−) EUR: (−) HDL: (+) LDL: (+) logTG: (−) TC: (+) |
MYRF |
| rs198434 (11:61483417:A:G) | HIS: P = 3.57E−10 | EUR: P = 2.54E-03 | logTG: P = 1.65E−03 |
HIS: (+) EUR: (+) logTG: (+) |
DAGLA | |
| DPA | rs198434 (11:61483417:A:G) | HIS: P = 3.67E−10 | NS | logTG: P = 1.65E−03 |
HIS: (−) logTG: (+) |
DAGLA |
| LA | rs518804 (11:57494487:C:A) | HIS: P = 1.62E−09 | EUR: P = 2.50E−03 |
HDL: P = 1.96E−06 logTG: P = 0.001 |
HIS: (+) EUR: (−) HDL: (−) logTG: (+) |
TMX2 |
| rs10751002 (11:63617634:G:T) | HIS: P = 1.36E−09 | NS |
LDL: P = 3.31E−12 TC: P = 5.74E−09 |
HIS: (+) LDL: (+) TC: (+) |
MARK2 | |
| rs1039018 (11:46909524:A:C) | HIS: P = 1.01E−09 | NS |
HDL: P = 2.85E−74 logTG: P = 4.5E−43 |
HIS: (+) HDL: (+) logTG: (−) |
LRP4 |
Table 4 shows the novel putative causal variants in each signal (credible set) identified from fine-mapping for PUFAs with replication and validation evidence in HIS (n = 1454). All variant positions are presented based on Human Genome Build 37. Variants that were not previously documented in the CHARGE GWAS meta-analysis of n-3 and n-6 PUFAs and were not in LD with known GWAS variants were considered novel in the current study. P-values corresponding to discovery (in HIS) and replication (in EUR) are calculated using a two-sided test for the z-score derived by meta-analysis including a total of n = 1454 or n = 2344 biologically independent samples, respectively. Validation P-values are extracted directly from the GWAS summary statistics corresponding to the GLGC publication25.