Table 1.
Baseline characteristics comparing aortic stenosis participants with and without diabetes
| Diabetes (n=56) | Non-diabetes (n=198) | P value | |
| Age | 70 (63–75) | 69 (61–75) | 0.361 |
| Sex, n (%) male | 44 (79) | 149 (75) | 0.608 |
| Ethnicity, n (%) white | 53 (95) | 195 (99) | 0.095 |
| Height, m | 1.68±0.10 | 1.70±0.09 | 0.121 |
| Weight, kg | 85.3±17.4 | 81.8±14.7 | 0.133 |
| Body mass index, kg/m2 | 30.1±5.2 | 28.0±4.2 | 0.003 |
| Systolic blood pressure, mm Hg | 146±21 | 142±22 | 0.287 |
| Diastolic blood pressure, mm Hg | 75±12 | 77±10 | 0.146 |
| Heart rate, bpm | 72±14 | 69±11 | 0.128 |
| HbA1c, mmol/mol | 51±11 | 38±4 | <0.001 |
| HbA1c, % | 6.8±1.0 | 5.7±0.4 | <0.001 |
| Medical history | |||
| Hypertension, n (%) | 45 (80) | 101 (51) | <0.001 |
| Hyperlipidaemia, n (%) | 35 (63) | 85 (43) | 0.010 |
| Smoking history, n (%) | 33 (59) | 110 (56) | 0.653 |
| Ischaemic heart disease, n (%) | 26 (46) | 77 (39) | 0.310 |
| Severe AS, n (%) | 48 (86) | 155 (78) | 0.220 |
| Symptomatic AS, n (%) | 22 (39) | 50 (25) | 0.040 |
| Medications | |||
| ACEi/ARB, n (%) | 38 (68) | 69 (35) | <0.001 |
| Beta blocker, n (%) | 24 (43) | 64 (33) | 0.158 |
| Diuretic, n (%) | 24 (43) | 47 (24) | 0.006 |
| Statin, n (%) | 50 (89) | 109 (56) | <0.001 |
| Bloods and valve severity | |||
| eGFR, mL/min/1.73 m2 | 71 (60–87) | 81 (66–96) | 0.022 |
| NTproBNP, pmol/L | 104 (39–257) | 73 (21–226) | 0.121 |
| hsTnI, pg/mL | 6.4 (4.1–10.7) | 5.5 (3.3–10.1) | 0.414 |
| AV peak velocity, m/s | 4.0±0.6 | 4.0±0.6 | 0.732 |
| AV maximum pressure gradient, mm Hg | 67±20 | 65±21 | 0.696 |
| AV mean pressure gradient, mm Hg | 38±12 | 39±14 | 0.936 |
| AV area, cm2 | 0.96±0.34 | 1.05±0.30 | 0.055 |
Data presented as mean (SD), median (IQR) or number (%) as appropriate.
ACEi, ACE inhibitor; ARB, angiotensin receptor blocker; AS, aortic stenosis; AV, aortic valve; eGFR, estimated glomerular filtration rate; HbA1c, glycated haemoglobin; hsTnI, High sensitivity troponin I; NTproBNP, N-terminal pro-B-type natriuretic peptide.