Table 3.
Cox regression models for primary composite endpoint and secondary endpoint
| Primary composite endpoint | Mortality endpoint | |||||||||||
| Baseline model (n=204) | Baseline+LGE (n=201) | Baseline+MPR (n=143) | Baseline+ECV (n=129) | Baseline (n=220) | Baseline+LGE (n=217) | |||||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | 1.09 (1.05 to 1.12) | <0.001 | 1.08 (1.05 to 1.11) | <0.001 | 1.09 (1.04 to 1.13) | <0.001 | 1.08 (1.03 to 1.12) | <0.001 | 1.04 (1.00 to 1.07) | 0.052 | 1.03 (0.98 to 1.07) | 0.091 |
| Diabetes | 1.34 (0.76 to 2.37) | 0.316 | 1.29 (0.72 to 2.30) | 0.395 | 1.75 (0.83 to 3.69) | 0.142 | 1.21 (0.55 to 2.65) | 0.636 | 2.04 (1.05 to 4.00) | 0.037 | 2.15 (1.10 to 4.20) | 0.026 |
| AV mean PG | 0.98 (0.97 to 1.00) | 0.089 | 0.98 (0.96 to 1.00) | 0.060 | 0.99 (0.97 to 1.02) | 0.604 | 0.99 (0.96 to 1.02) | 0.445 | 1.01 (0.99 to 1.04) | 0.265 | 1.01 (0.99 to 1.04) | 0.324 |
| AVR | 2.45 (1.09 to 5.51) | 0.031 | 3.08 (1.28 to 7.38) | 0.012 | 2.55 (0.86 to 7.58) | 0.093 | 2.27 (0.79 to 6.54) | 0.129 | 0.27 (0.11 to 0.63) | 0.002 | 0.31 (0.13 to 0.75) | 0.010 |
| LGE | NA | NA | 1.88 (1.08 to 3.30) | 0.027 | NA | NA | NA | NA | NA | NA | 1.90 (0.94 to 3.87) | 0.075 |
| MPR | NA | NA | NA | NA | 1.12 (0.63 to 1.99) | 0.710 | NA | NA | NA | NA | NA | NA |
| ECV | NA | NA | NA | NA | NA | NA | 1.02 (0.88 to 1.17) | 0.814 | NA | NA | NA | NA |
AVR, aortic valve replacement; PG, pressure gradient; LGE, late gadolinium enhancement; MPR, myocardial perfusion reserve; ECV, extracellular volume fraction; NA, not applicable.