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. 2023 Aug 16;11(8):e007199. doi: 10.1136/jitc-2023-007199

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Cytotoxic activities of EDB-targeting second-generation CAR or rTCR-CAR T cells in vitro. (A–C) CAR T cells are cytotoxic to EDB-positive U87MG, A549, and Raji cell lines, n=3. (D–G) T-cell activation markers CD69, CD25, CD107a, and Granzyme B were induced by incubation with U87MG and detected by flow cytometry or ELISA. Quantitation of CD69, CD25, and CD107a upregulation in transduced T cells from three individuals. Student’s two-tailed unpaired t-test was used to determine the statistical significance between the indicated groups. *p<0.05, **p<0.01, ***p<0.001. EDB, extra domain B.