Table 1.
List of biosensors for identifying respiratory infection biomarkers.
| Disease | Biosensor | Target | Probe | Material | Limit of detection | References |
|---|---|---|---|---|---|---|
| Pneumonia | Colorimetric assay | DNA | DNA | Gold | 1 pM | [27] |
| Pneumonia | DLS | Procalcitonin | Antibody | Magnetic | 0.03 pg/mL | [30] |
| Pneumonia | Colorimetric assay | S. aureus | Peptide | Gold and magnets | 7 CFU/mL | [32] |
| Influenza | LFA | Influenza virus | Aptamer and antibody | Gold | 2 × 106 virus particles | [65] |
| Influenza | Impedance sensor | Matrix protein | Antibody | Diamond | 1 pg/mL | [34] |
| Influenza A | Waveguide mode sensor | Influenza A virus | Aptamer | Gold | 8 × 103 PFU/mL | [41] |
| Influenza | LFA | Capsid protein | Antibody | Gold | 1:10,000 dilution | [66] |
| Influenza A | LOOP | cDNA | DNA | – | – | [67] |
| Influenza B | SPR | Influenza B virus | Aptamer | Silica | 7 ng/mL | [38] |
| SARS CoV-19 | Electrochemical sensor | Spike protein | Antibody | Gold | 1 pg/mL | [68] |
| SARS-CoV-2 | FET sensor | Spike protein | Antibody | Graphene | 1.6 × 101 PFU/mL | [50] |
| COVID-19 | Impedance spectroscopy | Spike protein | Antibody | Diamond | 189 fM | [49] |
| RSV | Cyclic voltammetry | F protein | Antibody | Gold | 1.1 × 103 PFU/mL | [60] |
| RSV | Cyclic voltammetry | F protein | Antibody | Glossy carbon | 2.85 × 106 PFU/mL | [60] |
| RSV | Fluorescence | DNA | DNA | Gold | 11.9 PFU | [62] |
| RSV | CARD | RSV | Antibody | Gold | 0.01 pg/mL | [63] |
| Salmonella | CRISPR | DNA | DNA | Gold | 1 CFU/mL | [25] |
| S. typhimurium | CRISPR | DNA | DNA | Dyna beads | 20 CFU/mL | [69] |
| TB | Colorimetric assay | ESAT-6 | Gold | 1.25 pM | [22] | |
| TB | Impedance | 16 kDA HSP | Antibody | Gold | 100 fM | [18] |
| TB | Electrochemical sensor | Aptamer | DNA | Gold | 100 CFU/mL | [70] |
| Staphylococcus aureus | CRISPR | MecA gene | Guide RNA | Silver | 10 fM | [71] |