Table 2.
Univariable Analyses of Factors Associated With Nondeterioration of ADL by TMIG-IADL at 6 Months After Surgery
| Factor | Classification | Number of Patients | Rate of No Deterioration (95% CI) | OR (95% CI) | p Value |
|---|---|---|---|---|---|
| Sex | Male | 491 | 82.7 (79.1–85.9) | 1 (reference) | |
| Female | 385 | 88.1 (84.4–91.1) | 0.648 (0.440–0.954) | 0.0280 | |
| Age (y) | ≤79 | 504 | 87.7 (84.5–90.4) | 1 (reference) | |
| ≥80 | 372 | 81.5 (77.1–85.3) | 1.624 (1.118–2.357) | 0.0108 | |
| Age (y) | ≤84 | 805 | 86.0 (83.4–88.3) | 1 (reference) | |
| ≥85 | 71 | 74.7 (62.9–84.2) | 2.080 (1.176–3.679) | 0.0119 | |
| Clinical stage | 0 | 29 | 86.2 (68.3–96.1) | 1 (reference) | |
| IA1 | 131 | 91.6 (85.5–95.7) | 0.573 (0.169–1.946) | 0.3720 | |
| IA2 | 254 | 87.4 (82.7–91.2) | 0.901 (0.294 – 2.757) | 0.8549 | |
| IA3 | 158 | 87.3 (81.1–92.1) | 0.906 (0.285–2.875) | 0.8667 | |
| IB | 134 | 79.9 (72.1–86.3) | 1.577 (0.506–4.915) | 0.4321 | |
| IIA | 36 | 94.4 (81.3–99.3) | 0.368 (0.062–2.169) | 0.2693 | |
| IIB | 96 | 74.0 (64.0–82.4) | 2.201 (0.697–6.948) | 0.1787 | |
| IIIA+B | 38 | 73.7 (56.9–86.6) | 2.232 (0.621–8.019) | 0.2184 | |
| ECOG Performance status | 0 | 717 | 87.6 (85.0–89.9) | 1 (reference) | |
| 1 | 152 | 73.7 (65.9–80.5) | 2.520 (1.650–3.850) | <0.0001 | |
| 2–4 | 7 | 71.4 (29.0–96.3) | 2.823 (0.539–14.767) | 0.2191 | |
| Smoking history | Never | 363 | 88.7 (85.0–91.8) | 1 (reference) | |
| Ever | 513 | 82.5 (78.9–85.7) | 1.671 (1.124–2.485) | 0.0112 | |
| Smoking years | 0 | 364 | 88.7 (85.0–91.8) | 1 (reference) | |
| 1–19 | 51 | 94.1 (83.8–98.8) | 0.493 (0.147–1.653) | 0.2518 | |
| 20–39 | 132 | 78.8 (70.8–85.4) | 2.121 (1.250–3.599) | 0.0053 | |
| ≥40 | 328 | 82.0 (77.4–86.0) | 1.728 (1.124–2.656) | 0.0127 | |
| Respiratory comorbidity | No | 588 | 87.9 (85.0–90.5) | 1 (reference) | |
| Yes | 288 | 79.2 (74.0–83.7) | 1.916 (1.314–2.795) | 0.0007 | |
| Emphysema | No | 623 | 87.3 (84.5–89.8) | 1 (reference) | |
| Yes | 253 | 79.5 (73.9–84.3) | 1.781 (1.211–2.620) | 0.0033 | |
| Interstitial pneumonia | No | 788 | 86.3 (83.7–88.6) | 1 (reference) | |
| Yes | 88 | 73.9 (63.4–82.7) | 2.228 (1.328–3.736) | 0.0024 | |
| Number of medications | 0 | 63 | 92.1 (82.4–97.4) | 1 (reference) | |
| 1-3 | 255 | 89.8 (85.4–93.2) | 1.317 (0.458–3.578) | 0.5893 | |
| 4-9 | 464 | 83.0 (79.2–86.3) | 2.380 (0.925–6.124) | 0.0721 | |
| ≥10 | 94 | 77.7 (67.9–85.6) | 3.337 (1.186–9.388) | 0.0224 | |
| Operation | Wedge Resection | 95 | 88.4 (80.2–94.1) | 1 (reference) | |
| Segmentectomy | 133 | 81.2 (73.5–87.5) | 1.768 (0.823–3.796) | 0.1441 | |
| Lobectomy | 639 | 85.5 (82.5–88.1) | 1.301 (0.668–2.531) | 0.4390 | |
| Bilobectomy | 6 | 83.3 (35.9–99.6) | 1.527 (0.163–14.305) | 0.7106 | |
| Pneumonectomy | 3 | 66.7 (9.4–99.2) | 3.818 (0.319–46.657) | 0.2899 | |
| Lymph node dissection | ND0–1 | 371 | 84.6 (80.6–88.2) | 1 (reference) | |
| ≥ND2a | 505 | 85.4 (82.0–88.3) | 0.946 (0.650–1.376) | 0.7708 | |
| Combined resection | No | 863 | 85.4 (82.9–87.7) | 1 (reference) | |
| Yes | 13 | 61.5 (31.6–86.1) | 3.656 (1.177–11.353) | 0.0250 | |
| Operation time | <180 min | 548 | 83.8 (80.4–86.8) | 1 (reference) | |
| ≥180 min | 328 | 87.2 (83.1–90.6) | 0.757 (0.510–1.125) | 0.1685 | |
| G8 score at registration | ≥15 | 380 | 90.5 (87.1–93.3) | 1 (reference) | |
| ≤14 | 495 | 80.8 (77.1–84.2) | 2.269 (1.506–3.149) | <0.0001 | |
| CCI score | 0 | 447 | 88.8 (85.5–91.6) | 1 (reference) | |
| ≥1 | 429 | 81.1 (77.1–84.7) | 1.848 (1.263–2.704) | 0.0016 |
ADL, activities of daily living; CCI, Charlson comorbidity index; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group; G8, geriatric screening tool; ND0, no node dissection; ND1, hilar node dissection; ND2, mediastinal node dissection; TMIG-IADL, Tokyo Metropolitan Institute of Gerontology Index of Competence Instrumental Activities of Daily Living.