Table 2.
Biopsy Characteristics of patients with biopsy-proven NASH, Borderline NASH, and steatosis.
| Biopsy characteristics | NASH (n = 1210) | Borderline NASH (n = 456) | Steatosis |
pa steatosis vs NASH | sb steatosis vs NASH | p Borderline NASH vs NASH | s Borderline NASH vs NASH | p Steatosis vs Borderline NASH | s Steatosis vs Borderline NASH |
|---|---|---|---|---|---|---|---|---|---|
| (n = 1341) | |||||||||
| Steatosis assessment | |||||||||
| Quantitative Steatosis grade, n (%) | |||||||||
| 1 | 162 (47.2) | 70 (79.5) | 238 (87.5) | <0.001 | 78.7 | <0.001 | 21.9 | 0.17 | 2.6 |
| 2 | 80 (23.3) | 11 (12.5) | 19 (7) | ||||||
| 3 | 101 (29.5) | 7 (8) | 15 (5.5) | ||||||
| Qualitative Steatosis assessment | |||||||||
| Macrovesicular, n (%) | 324 (26.8) | 112 (24.6) | 294 (21.9) | 0.005 | 7.7 | 0.39 | 1.4 | 0.27 | 1.9 |
| Microvesicular, n (%) | 21 (1.7) | 8 (1.8) | 24 (1.8) | 1 | <0.001 | 1 | <0.001 | 1 | <0.001 |
| Degree of steatosis, n (%) | |||||||||
| mild | 417 (55.9) | 166 (76.5) | 484 (84.4) | <0.001 | 89.4 | <0.001 | 22.9 | 0.03 | 5.1 |
| moderate | 256 (34.3) | 45 (20.7) | 76 (13.3) | ||||||
| severe | 73 (9.8) | 6 (2.8) | 13 (2.3) | ||||||
| Steatohepatitis assessment | |||||||||
| NLP identified key word: Steatohepatitis, n (%) | 1210 (100) | 0 (0) | 0 (0) | ||||||
| Degree of steatohepatitis, n (%) | |||||||||
| mild | 402 (74.4) | 0 (0) | 0 (0) | ||||||
| moderate | 122 (22.6) | 0 (0) | 0 (0) | ||||||
| severe | 16 (3) | 0 (0) | 0 (0) | ||||||
| NLP identified key word: Ballooning, n (%) | 193 (16) | 67 (14.7) | 0 (0) | 0.58 | 0.8 | ||||
| Fibrosis grade, n (%) | |||||||||
| 1 | 57 (52.8) | 5 (62.5) | 16 (47.1) | 0.046 | 4.5 | 0.39 | 1.4 | 1 | 0 |
| 2 | 23 (21.3) | 3 (37.5) | 13 (38.2) | ||||||
| 3 | 26 (24.1) | 0 (0) | 3 (8.8) | ||||||
| 4 | 2 (1.8) | 0 (0) | 2 (5.9) | ||||||
| NLP identified key word: Fibrosis, n (%) | 146 (12.1) | 398 (87.3) | 0 (0) | <0.001 | 617.3 | ||||
| NLP identified key word: Cirrhosis, n (%) | 220 (18.2) | 0 (0) | 0 (0) |
NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis.
a
p; p-value obtained from Pearson's chi-squared test for categorical variables; with exception for fibrosis grade, the p-value obtained from Fisher’s exact test, as more than 20% of the cells have frequency <5. All variables were non-normally distributed.
b
s; s-value obtained from formula: s-value = −log2 (p-value).