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. 2023 Aug 16;220(11):e20230577. doi: 10.1084/jem.20230577

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© 2023 Yang et al.

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Figure 6. — Metoprolol relieves CRS in patients receiving CAR T therapy. (A and B) Body temperatures in patients who received metoprolol conditional monotherapy were monitored at the indicated time points after CAR T infusion. Individual patient data in A and cumulative results from eight patients including #0 in B; the highest value of body temperature on a given day were shown. (C–E) Levels of serum IL-6 in patients who received metoprolol conditional monotherapy were measured at the indicated time points after CAR T infusion. Individual patient data in C and cumulative results from eight patients including #0 in D and E. (F) Serum CRP levels in patients who received metoprolol conditional monotherapy were measured at the indicated time points after CAR T infusion. Cumulative results from eight patients including #0. (G and H) Body temperatures (G) and serum IL-6 levels (H) in patients who received metoprolol prophylactic monotherapy were measured at the indicated time points after CAR T infusion. (I) CRS and ICANS grades of patients who received metoprolol treatments (n = 16) were determined. (J) PBMCs were isolated from the peripheral blood of patient #10, #13, and #15 before and after metoprolol treatment. IL6 mRNA levels were measured by qPCR and serum IL-6 levels were measured by ELISA. Data are presented as mean ± SEM in B, E, and F; **P < 0.01, ****P < 0.0001, ns, not significant; two-tailed paired t test in B and D.