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. 2023 Aug 8;31:53–62. doi: 10.1016/j.bioactmat.2023.07.026

Fig. 3.

Fig. 3

MMP NDs induced ferroptosis. (a) Endocytosis of MMP-Cy5.5 NDs (scale bar: 20 μm). (b&c) Relative viabilities of (b) normal cells (HUVECs and DC2.4) and (c) tumor cells (CT26, 4T1 and B16F10) after incubation with different concentrations of MMP NDs for 12 h. (d) Apoptosis detection of CT26 cells after incubation with MMP NDs. (e) Statistical data of apoptosis in (d). (f) MDA content in MMP NDs treated CT26 cells. (g) MMP NDs treated CT26 cells were stained with DCFH-DA and ThiolTracker violet probe (scale bar: 20 μm). (h) The expression of GPX4 in MMP NDs treated CT26 cells was evaluated by WB. (i) Scheme of ferroptosis of tumor cells triggered by MMP NDs.