Table 1.
Some last studies about long non-coding RNAs (lncRNAs)-microRNAs (miRNAs) interactions in glioma.
| LncRNAs | Expression of lncRNAs | miRNAs | Targets | Function | Ref. |
|---|---|---|---|---|---|
| HOXA11-AS | Up | let-7b-5p | Tpl2-MEK1/2-ERK1/2 axis | Sensitizes glioblastoma cells to ROS, drastically impairing tumor growth and prolonging survival of mouses | [57] |
| MIR210HG | Down | miR-377–3p | LMX1A | Suppresses glioma cell proliferation | [58] |
| PDCD4-AS1 | Down | miR-30b-3p | METTL7B | Inhibits glioma cell proliferation, invasion, migration, and induces cell cycle arrest | [59] |
| GSCAR | Down | miR-6760–5p | SRSF1 | Promotes tumor cell responses to TMZ | [60] |
| SPRY4-IT1 | Down | miR-101–3p | EZH2 and VEGFA | Achieves cell proliferation and angiogenesis | [61] |
| LINC01018 | Up | miR-942–5p | KNG1 | Suppresses the migration, invasion, and proliferation of glioma cells | [62] |
| LINC01018 | Up | miR-182–5p | ADRA2C, RAB6B, RAB27B, RAPGEF5, STEAP2, TAGLN3, and UNC13C | Inhibits cell proliferation and metastasis | [63] |
| TUSC7 | Up | miR-10a-5p | BDNF/ERK axis | Suppresses glioma cell proliferation and migration | [64] |
| LINC01426 | Down | miR-661 | Mdm2 | Inhibits proliferation and induces apoptosis | [65] |
| DANCR | Up | miR-33b | DLX6/ATG7 axis | Promotes intracellular autophagy and proliferation and reduce apoptosis | [66] |
Abbreviations: MIR210HG, MIR210 Host Gene; PDCD4-AS1, PDCD4 Antisense RNA 1; GSCAR, Glioma stem cell associated lncRNA; SPRY4-IT1, Sprouty RTK signaling antagonist 4-intronic transcript 1; LINC01018, Long Intergenic Non-Protein Coding RNA 1018; TUSC7, Tumor Suppressor Candidate 7; LINC01426, Long Intergenic Non-Protein Coding RNA 1426; DANCR, Differentiation Antagonizing Non-Protein Coding RNA; TMZ, Temozolomide; Tpl2, Tumor progression locus 2; MEK1/2, Mitogen-activated protein kinase kinase 1/2; ERK1/2, Extracellular signal-regulated kinase 1/2; LMX1A, LIM Homeobox Transcription Factor 1 Alpha; METTL7B, Methyltransferase-like 7B; SRSF1, Serine/arginine-rich splicing factor 1; EZH2, Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit; VEGFA, Vascular endothelial growth factor A; KNG1, Kininogen 1; ADRA2C, Adrenoceptor Alpha 2C; RAB6B, Ras-related protein Rab-6B; RAB27B, Ras-related protein Rab-27B; RAPGEF5, Rap guanine nucleotide exchange factor 5; STEAP2, Six-transmembrane epithelial antigen of the prostate-2; TAGLN3, Transgelin 3; UNC13C, unc-13 homolog C; BDNF, Brain-derived neurotrophic factor; ERK, Extracellular signal-regulated kinases; Mdm2, Mouse double minute 2 homolog; DLX6, Distal-Less Homeobox 6; ATG7, Autophagy Related 7.