Fig. 2.
Most SARS-CoV-2 spike S1-specific BMPC express IgG. (a) Expression of IgA and IgM by total and SARS-CoV-2 specific BMPC. IgA−IgM− BMPC are considered IgG+ PC, based on previous data and scarcity of IgE+ or IgD+ PC (<3% of BMPC,4,17 and unpublished data). Dot plots display concatenated data of all donors. Summary for total (b) and RBD/S1 BMPC (c). (d) Frequencies of RBD/S1 BMPC among BMPC expressing different Ig isotypes. Medians and IQR are indicated. Friedman test with Dunn's multiple test correction was applied. Data of 16 donors are shown.