Overexpressing SIRT3 plus PARP inhibition with olaparib fully restores hexokinase activity in quadriceps of AR100Q mice
Levels of Hexokinase in quadriceps from WT, AR100Q, and AR100Q-SIRT3 male mice (n = 3) at age 11 weeks fed no-drug compounded or olaparib-compounded food. All statistical analysis show mean ± SD, and used a two-way ANOVA and Tukey’s post-hoc (∗∗∗ = p ≤ 0.001). WT, wild type; SIRT3, SIRT3-flag overexpression; AR100Q, polyQ-expanded AR; AR100Q-SIRT3, polyQ-expanded AR with SIRT3-flag overexpression; olaparib, PARP inhibitor (1150 g of olaparib in 1 kg of feed).