REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
mouse α-tubulin IgG1	Sigma-Aldrich	Cat# T6199; RRID: AB_477583
mouse-myc IgG1	Thermo Fisher Scientific	Cat# R950-25; RRID: AB_2556560
mouse SOD2-A2 IgG2b	Santa Cruz	Cat# sc-133134; RRID: AB_2191814
rabbit acetyl K68 SOD2 IgG	Abcam	Cat# ab137037; RRID: AB_2784527
mouse anti-Poly-ADP-Ribose IgG3	Trevigen	Cat# 4335-MC-100; RRID: AB_2572318
rabbit SIRT3	Cell Signaling	Cat# 5490; RRID: AB_10828246
rabbit mAb androgen receptor	Cell Signaling	Cat# 5153; RRID: AB_10691711
mouse ANTI-FLAG® M2	Sigma	Cat# F1804; RRID: AB_262044
Goat anti-rabbit IgG-HRP	Thermo Fisher Scientific	Cat# 65-6120; RRID: AB_2533967
Goat anti-mouse IgG1-HRP	Thermo Fisher Scientific	Cat# A10551; RRID: AB_2534048
Goat anti-mouse IgG2B-HRP	Novus	Cat# NB7521; RRID: AB_10124376
Goat anti-mouse IgG3-HRP	Thermo Fisher Scientific	Cat# M32607; RRID: AB_2536651
Chemicals, peptides, and recombinant proteins
honokiol	Tocris	4590
viniferin	Carbosynth	FV30429
melatonin	Tocris	3550
olaparib	Selleck Chemicals	AZD2281
tert-butyl hydroperoxide solution	Sigma	75-91-2
DHT (5A-ANDROSTAN-17B-OL-3-ONE)	Sigma	A8380-1G
EtOH (200 proof)	Electron Microscopy Sciences	15055
DMSO	Fisher BioReagents™	BP231100
protease inhibitor tablets	Thermo Scientific	A32963
SuperSignal TM West Pico Plus Chemiluminescent Substrate	Thermo Scientific	34577
Critical commercial assays
DCFDA/H2DCFDA kit	Abcam	ab113851
LDH assay kit	Cayman Chemical	601170
NAD+ assay kit	BioAssay Systems	E2ND-100
Negative Control Magnetic Resin	Tulip Biolabs	2427
PAR WWE Domain Magnetic Affinity Resin assay	Tulip Biolabs	2438
Hexokinase assay kit	Abcam	ab136957
DC protein assay kit	Biorad	5000112
Experimental models: Cell lines
Tet-inducible AR112Q and AR24Q PC12 cell lines	Walcott and Merry37	N/A
AR100Q and AR24Q C2C12 cell lines	Milioto et al.38	N/A
Experimental models: Organisms/strains
pCAGGS-AR100Q and pCAGGS-AR24Q transgenic mice	Chivet et al.30	N/A
CAG-SIRT3M1 transgenic mice	N/A	N/A
PARP-1 KO mice (129S-Parp1tm1Zqw/J)	Wang et al.55	JAX: 002779
Recombinant DNA
pCDNA4-Myc-HisB-Sirt3	Ahn et al.39	Addgene: 24918
pCDNA4-Myc-HisA-H248Y-Sirt3	Ahn et al.39	Addgene: 24917
Software and algorithms
Graph Pad Software Prism 8
Limma package
Ingenuity Pathway Analysis software