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. Author manuscript; available in PMC: 2023 Aug 17.
Published in final edited form as: J Med Chem. 2023 Jan 6;66(2):1543–1561. doi: 10.1021/acs.jmedchem.2c01745

Table 6.

Inhibitory Activity of Benzyl Compounds (Intermediates for Precursors)a

graphic file with name nihms-1924247-t0036.jpg
Comp’d P4 PDE4D* PDE4B* Selectivity
R4 = IC50 (nM) IC50 (nM) B/D
57 graphic file with name nihms-1924247-t0037.jpg 164 >10000 >61
58 graphic file with name nihms-1924247-t0038.jpg 610 >7763 >13
59 graphic file with name nihms-1924247-t0039.jpg 174 >10000 >57
60 graphic file with name nihms-1924247-t0040.jpg 446 274 0.61
61 graphic file with name nihms-1924247-t0041.jpg 171 143 0.84
62 graphic file with name nihms-1924247-t0042.jpg 85 46 0.54
a

See Table 1 for assay definitions.