Table 4.
Pulmonary hemodynamic parameters—mean change (sd) from baseline at maximum increase and at maximum decrease.
| Parameter | Hypertension Group (N = 18) | Normal Group (N = 18) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | Lumason | Placebo | Baseline | Lumason | Placebo | |||||
| Max Dec | Max Inc | Max Dec | Max Inc | Max Dec | Max Inc | Max Dec | Max Inc | |||
| PAPs (mmHg) | N = 18 | N = 16 | N = 11 | N = 15 | N = 9 | N = 18 | N = 11 | N = 14 | N = 10 | N = 16 |
| Mean (SD) | 50.50 (17.581) | −6.719 (5.174) | 2.818 (2.000) | −6.367 (5.034) | 4.111 (3.008) | 30.08 (6.001) | −3.500 (3.391) | 3.071 (0.917) | −3.400 (3.486) | 4.188 (3.728) |
| 95% CIs (LL, UL) | (−9.476, −3.962) | (1.415, 4.222) | (−9.154, −3.579) | (1.799, 6.423) | (−5.778, −1.222) | (2.542, 3.601) | (−5.894, −0.906) | (2.201, 6.174) | ||
| PAPd (mmHg) | N = 18 | N = 16 | N = 11 | N = 16 | N = 8 | N = 18 | N = 11 | N = 17 | N = 9 | N = 17 |
| Mean (SD) | 24.11 (7.177) | −6.813 (6.516) | 3.000 (1.225) | −5.938 (4.701) | 2.813 (1.907) | 11.72 (3.750) | −2.364 (2.820) | 2.853 (3.220) | −2.389 (2.583) | 3.324 (2.910) |
| 95% CIs (LL, UL) | (−10.285, −3.340) | (2.177, 3.823) | (−8.442, −3.433) | (1.218, 4.407) | (−4.258, −0.469) | (1.197, 4.508) | (−4.375, −0.403) | (1.827, 4.820) | ||
| MPAP (mmHg) | N = 18 | N = 11 | N = 11 | N = 13 | N = 8 | N = 18 | N = 9 | N = 14 | N = 9 | N = 17 |
| Mean (SD) | 34.19 (10.072) | −5.636 (2.703) | 2.773 (2.504) | −5.731 (3.251) | 3.375 (3.137) | 20.00 (4.040) | −2.222 (2.265) | 2.429 (1.719) | −1.778 (1.417) | 2.735 (1.697) |
| 95% CIs (LL, UL) | (−7.452, −3.821) | (1.091, 4.455) | (−7.695, −3.766) | (0.753, 5.997) | (−3.964, −0.481) | (1.436, 3.421) | (−2.867, −0.689) | (1.863, 3.608) | ||
| PCWP (mmHg) | N = 18 | N = 12 | N = 10 | N = 9 | N = 9 | N = 18 | N = 7 | N = 9 | N = 10 | N = 7 |
| Mean (SD) | 18.8 (7.15) | −3.500 (3.289) | 4.400 (4.061) | −4.556 (3.712) | 5.444 (5.411) | 12.3 (4.60) | −3.000 (2.236) | 3.444 (2.242) | −2.000 (1.414) | 3.286 (2.928) |
| 95% CIs (LL, UL) | (−5.590, −1.410) | (1.495, 7.305) | (−7.409, −1.702) | (1.285, 9.604) | (−5.068, −0.932) | (1.721, 5.168) | (−3.012, −0.988) | (0.578, 5.993) | ||
| Qp (litres/min) | N = 18 | N = 13 | N = 9 | N = 13 | N = 9 | N = 18 | N = 8 | N = 14 | N = 10 | N = 12 |
| Mean (SD) | 4.926 (2.1058) | −0.645 (0.643) | 0.560 (0.333) | −0.728 (0.465) | 0.847 (0.512) | 4.763 (1.4543) | −0.449 (0.442) | 0.729 (0.742) | −0.503 (0.520) | 0.559 (0.540) |
| 95% CIs (LL, UL) | (−1.033, −0.256) | (0.304, 0.816) | (−1.118, −0.339) | (0.453, 1.240) | (−0.818, −0.079) | (0.300, 1.157) | (−0.875, −0.131) | (0.216, 0.903) | ||
| Heart Rate (bpm) | N = 18 | N = 10 | N = 8 | N = 9 | N = 9 | N = 18 | N = 9 | N = 9 | N = 8 | N = 9 |
| Mean (SD) | 80.1 (8.71) | −6.000 (5.375) | 5.500 (6.782) | −8.444 (8.233) | 5.000 (5.408) | 77.7 (17.08) | −3.444 (2.651) | 4.667 (7.858) | −3.250 (4.803) | 4.556 (3.877) |
| 95% CIs (LL, UL) | (−9.845, −2.155) | (−0.170, 11.170) | (−14.773, −2.116) | (0.843, 9.157) | (−5.482, −1.407) | (−1.374, 10.707) | (−7.266, 0.766) | (1.576, 7.535) | ||
| Stroke Volume (mL) | N = 18 | N = 13 | N = 11 | N = 14 | N = 10 | N = 18 | N = 7 | N = 15 | N = 11 | N = 11 |
| Mean (SD) | 62.365 (27.201) | −7.990 (7.717) | 6.536 (5.787) | −9.363 (7.861) | 12.944 (14.437) | 62.322 (18.749) | −5.492 (4.104) | 8.680 (9.415) | −6.624 (7.501) | 7.614 (5.873) |
| 95% CIs (LL, UL) | (−12.653, −3.326) | (2.648, 10.424) | (−13.902, −4.824) | (2.617, 23.271) | (−9.288, −1.697) | (3.466, 13.894) | (−11.663, −1.585) | (3.669, 11.559) | ||
| PVR (dyne x s/cm5) | N = 18 | N = 11 | N = 12 | N = 16 | N = 9 | N = 18 | N = 11 | N = 11 | N = 10 | N = 14 |
| Mean (SD) | 307.19 (307.63) | −138.515 (169.020) | 78.254 (68.614) | −121.318 (220.423) | 74.843 (74.211) | 142.71 (93.61) | −47.834 (40.484) | 43.119 (39.393) | −40.815 (36.466) | 66.246 (73.625) |
| 95% CIs (LL, UL) | (−252.064, −24.966) | (34.659, 121.849) | (−238.773, −3.862) | (17.799, 131.887) | (−75.032, −20.636) | (16.654, 69.583) | (−66.901, −14.729) | (23.737, 108.756) | ||
The number of subjects with increases are included in the summary for maximum increase and those with decreases are included in the summary for maximum decrease; subjects with no change are not included.
Max Inc, Mean change from baseline at maximum increase; Max Dec, Mean change from baseline at maximum decrease; LL, Lower Limit; UL, Upper Limit.