Table 4.
Cox Regression models for the secondary endpoint of heart failure hospitalizations
| Heart failure hospitalizations | Univariable analyses | Multivariable model 2a Imaging parameter without RV GLS |
Multivariable model 2b Imaging parameter with additional RV GLS |
Multivariable model 2c Imaging parameter with RV GLS instead LV GLS |
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|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | |
| Clinical characteristics | ||||||||
| Age [years] | 1.01 (0.99–1.03) | 0.145 | ||||||
| Gender [male] | 0.46 (0.26–0.83) | 0.010 | ||||||
| Troponin T peaka [ng/l] | 1.00 (0.99–1.00) | 0.356 | ||||||
| NT-proBNPa [log pg/ml] | 3.45 (1.70–6.90) | < 0.001 | ||||||
| CMR LGE | ||||||||
| LV LGE present | 1.36 (0.71–2.60) | 0.350 | ||||||
| LV LGE involves insertion points | 0.75 (1.32–1.79) | 0.525 | ||||||
| LV LGE extent FWHM [g] | 1.05 (1.02–1.08) | 0.003 | 1.03 (1.00–1.06) | 0.061 | 1.03 (1.00–1.06) | 0.064 | 1.03 (1.00–1.06) | 0.063 |
| RV LGE presenta | 2.33 (0.96–5.67) | 0.062 | ||||||
| CMR ejection fraction | ||||||||
| LV EF [%] | 0.93 (0.91–0.95) | < 0.001 | 1.00 (0.95–1.05) | 0.962 | 1.00 (0.95–1.05) | 0.943 | 0.96 (0.93–0.99) | 0.012 |
| RV EF [%] | 0.91 (0.89–0.93) | < 0.001 | 0.96 (0.93–0.99) | 0.038 | 0.97 (0.93–1.01) | 0.179 | 0.97 (0.94–1.02) | 0.226 |
| CMR feature tracking | ||||||||
| LV GLS [%] | 1.38 (1.28–1.50) | < 0.001 | 1.26 (1.07–1.48) | 0.007 | 1.22 (1.02–1.44) | 0.025 | ||
| LV GCS [%] | 1.30 (1.21–1.39) | < 0.001 | ||||||
| LV GRS [%] | 0.85 (0.81–0.89) | < 0.001 | ||||||
| RV GLS [%] | 1.17 (1.12–1.23) | < 0.001 | 1.05 (0.98–1.13) | 0.195 | 1.07 (1.01–1.15) | 0.048 | ||
| Model Chi-Square | 62.5 | 85.2 | 80.8 | |||||
| Df | 4 | 5 | 4 | |||||
| p value | < 0.001 | < 0.001 | < 0.001 | |||||
| −2 Log-Likelihood | 313.0 | 311.3 | 316.8 | |||||
| p-value vs. model without RV GLS | 0.194 | 0.048 | ||||||
CI: confidence intervals; EF: ejection fraction; Df: degrees of freedom; FWHM: full width half max; GCS/GLS/GRS: global circumferential/longitudinal/radial strain; HR: Hazard ratio; LGE: late gadolinium enhancement; LV: left ventricle; NT-proBNP: N-terminal pro-hormone brain natriuretic peptide; RV: right ventricle
aVariables with > 20% missing values. Troponin was available in 338 (51.3%) patients. NT-proBNP was available in 159 (24.1%) of patients. RV LGE was not assessable in 270 (41%) of patients