Table 5.
Cox Regression Models for the secondary endpoint of all-cause mortality
| Death | Univariable analyses | Multivariable model 3a Imaging parameter without RV GLS |
Multivariable model 3b Imaging parameter with additional RV GLS |
Multivariable model 3c Imaging parameter with RV GLS instead LV GLS |
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|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | HRadjusted (95% CI) | p value | |
| Clinical characteristics | ||||||||
| Age [years] | 1.05 (1.03–1.07) | < 0.001 | ||||||
| Gender [male] | 0.53 (0.29–0.97) | 0.040 | ||||||
| Troponin peaka [ng/l] | 1.00 (0.99–1.00) | 0.173 | ||||||
| NT-proBNPa [log pg/ml] | 5.01 (1.83–13.7) | 0.002 | ||||||
| CMR LGE | ||||||||
| LV LGE present | 1.22 (0.63–2.35) | 0.551 | ||||||
| LV LGE involves insertion points | 1.38 (0.66–2.92) | 0.394 | ||||||
| LV LGE extent FWHM [g] | 1.03 (0.99–1.07) | 0.153 | ||||||
| RV LGE presenta | 1.41 (0.54–3.65) | 0.481 | ||||||
| CMR ejection fraction | ||||||||
| LV EF [%] | 0.97 (0.95–0.99) | < 0.001 | 1.00 (0.96–1.04) | 0.951 | 1.00 (0.96–1.04) | 0.935 | 0.98 (0.96–1.01) | 0.283 |
| RV EF [%] | 0.96 (0.94–0.98) | 0.001 | 0.98 (0.94–1.01) | 0.215 | 0.98 (0.95–1.02) | 0.346 | 0.98 (0.95–1.02) | 0.348 |
| CMR feature tracking | ||||||||
| LV GLS [%] | 1.14 (1.06–1.21) | < 0.001 | 1.08 (0.93–1.24) | 0.310 | 1.06 (0.92–1.23) | 0.393 | ||
| LV GCS [%] | 1.10 (1.04–1.17) | 0.001 | ||||||
| LV GRS [%] | 0.95 (0.92–0.98) | 0.001 | ||||||
| RV GLS [%] | 1.07 (1.02–1.12) | 0.004 | 1.02 (0.96–1.09) | 0.526 | 1.03 (0.96–1.09) | 0.405 | ||
| Model Chi-Square | 15.2 | 15.9 | 14.9 | |||||
| Df | 3 | 4 | 3 | |||||
| p value | 0.002 | 0.003 | 0.002 | |||||
| −2 Log-Likelihood | 440.0 | 439.6 | 440.8 | |||||
| p-value vs. model without RV GLS | 0.528 | 0.408 | ||||||
CI: confidence intervals; EF: ejection fraction; Df: degrees of freedom; FWHM: full width half max; GCS/GLS/GRS: global circumferential/longitudinal/radial strain; HR: Hazard ratio; LGE: late gadolinium enhancement; LV: left ventricle; NT-proBNP: N-terminal pro-hormone brain natriuretic peptide; RV: right ventricle
aVariables with > 20% missing values. Troponin was available in 338 (51.3%) patients. NT-proBNP was available in 159 (24.1%) of patients. RV LGE was not assessable in 270 (41%) of patients