Table 1.

Study of mechanisms and complications of COVID-19 using spatial transcriptomics

Strategy	Species	Application	Ref.
RNA-ISH and GeoMx DSP	Human	Spatiotemporal heterogeneity of SARS-CoV-2 infection	[113]
RNAscope and GeoMx DSP	Human	Revealed distinct ACE2 expression loci	[116]
GeoMx DSP	Human	Mechanism of ARDS by SARS-CoV-2	[115]
RNAscope and GeoMx DSP	Human	Generate COVID-19 related lung spatial atlas	[69]
GeoMx DSP	Human	Identification of COVID-19 therapeutic target	[117]
RNAscope and GeoMx DSP	Human	Investigation of the pathogenesis of SARS-COV-2	[118]
GeoMx DSP	Human	SARS-COV-2 infection up-regulates inflammatory response in COPD patients	[119]
RNA-ISH and GeoMx DSP	Mouse	Mechanism of PASC	[114]
RNAscope	Human	Revealed the responses to SARS-CoV-2-induced exudative DAD	[120]
Visium	Mouse	A dynamic change in the location of T helper cells as well as their corresponding chemokines	[121]
RNAscope and GeoMx DSP	Human	Construction of immune-mediated histopathology model of COVID-19	[122]
Visium	Human	The interaction between chemokines and receptors in the pathogenesis of COVID-19 lung niche	[123]
Visium, RNAscope and GeoMx DSP	Human	Map Immune Responses to SARS-CoV-2	[124]

RNA-ISH RNA-in situ hybridization, GeoMx DSP GeoMx digital spatial profiler, ACE2 angiotensin converting enzyme 2, COVID-19 corona virus disease 2019, SARS-CoV2 severe acute respiratory syndrome coronavirus 2, ARDS acute respiratory distress syndrome, COPD chronic obstructive pulmonary diseases, PASC post-acute sequelae of SARS-CoV2, DAD diffuse alveolar damage