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. 2023 Jul 25;26(3):391. doi: 10.3892/ol.2023.13977

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Copyright: © Kawabe et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — GRHL2 is expressed at high levels in lung cancer. (A) Expression analysis of GRHL2 in lung adenocarcinoma and squamous cell carcinoma in TCGA dataset. (B) Meta-analysis of GRHL2 expression in lung adenocarcinoma and squamous cell carcinoma from six studies. T, tumor, N, normal, RE, random effects. (C) DNA copy number analysis of GRHL2 showing frequent increases in the copy number of GRHL2 in NSCLC cell lines. (D) Kaplan-Meier survival curves for patients with high or low GRHL2 expression (the cut-off value is the median expression level). (E) Survival meta-analysis for GRHL2 in adenocarcinoma (left) and squamous cell carcinoma (right). In each forest plot, the name of each study is followed by the number of total tumor samples. GRHL2, Grainyhead-like 2; SMD, standardized mean difference; TE, estimated treatment effect; seTE, standard error of treatment effect; HR, hazard ratio; CI, confidence interval, TCGA, The Cancer Genome Atlas; NSCLC, non-small cell lung cancer.