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. 2023 Jul 25;26(3):391. doi: 10.3892/ol.2023.13977

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Copyright: © Kawabe et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — GRHL2 is associated with an epithelial phenotype in lung cancer. (A) Western blotting of GRHL2, E-cadherin and Vimentin in a panel of lung cancer and immortalized bronchial epithelial cell lines. Values below bands indicate the semi-quantitation of band intensities normalized to β-actin. (B) Correlations between bands intensities of GRHL2 and E-cadherin (left graph) or Vimentin (right graph) in (A). Correlation analysis between the expression of GRHL2, E-cadherin, VIMENTIN and six master epithelial-to-mesenchymal transition regulator genes in (C) adenocarcinomas and (D) squamous cell carcinomas in The Cancer Genome Atlas dataset. The degrees of positive or negative correlation, revealed by Pearson's correlation coefficients, are colored by the darkness of purple or blue, respectively. GRHL2, Grainyhead-like 2; ZEB, Zinc finger E-box-binding homeobox; SNAI, snail homolog.