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GRHL2 knockdown promotes the phosphorylation of AKT and ERK in HBEC4KT and lung cancer cell lines. Western blotting of GRHL2, p- or total AKT and p- or total ERK in HBEC4KT, H1975 and H2009 cells transfected with control or GRHL2 siRNA. Values below bands indicate the semi-quantitation of band intensities normalized to AKT for p-AKT (ser473), ERK for p-ERK or β-actin for GRHL2. GRHL2, Grainyhead-like 2; siRNA, small-interfering RNA; NC, negative control; p-, phosphorylated.
