. 2023 Jul 25;26(3):391. doi: 10.3892/ol.2023.13977

Table I.

Univariate and multivariate analyses of cox multivariate regression analysis in adenocarcinoma in TCGA cohort.

	Univariate analysis			Multivariate analysis

Variables	HR	95% CI	P-value	HR	95% CI	P-value
Sex
Female	Reference			Reference
Male	0.9058	0.632–1.298	0.5903	0.8083	0.5362–1.219	0.3097
Age, years
>65	Reference			Reference
≤65	0.7696	0.5353–1.107	0.1575	0.6787	0.4589–1.004	0.0522
Smoking status
Never	Reference			Reference
Former	0.9214	0.5095–1.666	0.7864	1.2300	0.6490–2.332	0.5255
Current	0.7176	0.3668–1.404	0.3324	0.7643	0.3741–1.561	0.4609
Stage
I	Reference			Reference
II	2.516	1.582–4.002	<0.0001^a	3.0790	1.8620–5.091	<0.0001^a
III	4.426	2.774–7.062	<0.0001^a	4.8250	2.9390–7.922	<0.0001^a
IV	3.266	1.665–6.407	0.0006^a	4.4210	2.1770–8.981	<0.0001^a
GRHL2 mRNA
Low	Reference			Reference
High	0.9162	0.6413–1.309	0.1575	0.9025	0.6140–1.327	0.6018

P<0.05. GRHL2 expression levels were classified as high and low with median as the cut-off value. HR, hazard ratio; GRHL2, grainyhead-like 2; CI, confidence interval.