Table II.
Univariate and multivariate analyses of cox multivariate regression analysis in squamous cell carcinoma in TCGA cohort.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Variables | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Sex | ||||||
| Female | Reference | Reference | ||||
| Male | 1.038 | 0.7188–1.498 | 0.8434 | 1.0120 | 0.6924–1.478 | 0.9528 |
| Age, years | ||||||
| >65 years | Reference | Reference | ||||
| ≤65 years | 0.767 | 0.5447–1.080 | 0.1286 | 0.6727 | 0.4708–0.9611 | 0.0294 |
| Smoking status | ||||||
| Never | Reference | Reference | ||||
| Former | 0.4628 | 0.1695–1.264 | 0.1327 | 0.4100 | 0.1462–1.150 | 0.0903 |
| Current | 0.5929 | 0.2114–1.663 | 0.3205 | 0.5453 | 0.1894–1.570 | 0.2611 |
| Stage | ||||||
| I | Reference | Reference | ||||
| II | 1.202 | 0.8161–1.771 | 0.3514 | 1.1420 | 0.7654–1.704 | 0.5150 |
| III | 1.499 | 0.9979–2.251 | 0.0512 | 1.6030 | 1.060–2.424 | 0.0254 |
| IV | 2.042 | 0.6373–6.542 | 0.2295 | 1.8550 | 0.5745–5.992 | 0.3014 |
| GRHL2 mRNA | ||||||
| Low | Reference | Reference | ||||
| High | 1.008 | 0.7317–1.387 | 0.963 | 0.9540 | 0.6845–1.330 | 0.7812 |
GRHL2 expression levels were classified as high and low with median as the cut-off value. HR, hazard ratio; CI, confidence interval; GRHL2, grainyhead-like 2.