During the first trial period, all the infants with opioid withdrawal
were cared for according to the usual-care practices at each site. At a randomly
assigned time, each site entered a 3-month transition period, which included
training and implementation activities at the site. After this transition, the
infants with opioid withdrawal were cared for according to the Eat, Sleep,
Console approach along with its care tool. Details regarding the intervention
and the processes for training and implementation are provided in Figures S2 through S4 in the Supplementary Appendix.