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. Author manuscript; available in PMC: 2023 Dec 22.
Published in final edited form as: N Engl J Med. 2023 Apr 30;388(25):2326–2337. doi: 10.1056/NEJMoa2214470

Table 1.

Maternal and Neonatal Characteristics at Baseline.*

Characteristic Usual Care
(N = 702)
Eat, Sleep, Console
Care Approach
(N=603)
Maternal
Median gravidity (IQR) — no. 3 (2–5) 4 (2–5)
Median parity (IQR) — no. 3 (2–4) 3 (2–4)
Race or ethnic group — no. (%)
 Non-Hispanic White 462 (66) 447 (74)
 Non-Hispanic Black 98 (14) 71(12)
 Hispanic 107 (15) 33 (5)
 Other 25 (4) 37 (6)
 Missing data 10 (1) 15 (2)
Adequate prenatal care — no. (%)
 Yes 432 (62) 381 (63)
 Missing data 21 (3) 9 (1)
Medication for opioid use disorder — no./total no. (%)
 Any 512/702 (73) 451/603 (75)
  Buprenorphine 316/512 (62) 288/451 (64)
  Methadone 191/512 (37) 154/451 (34)
  Other 0 2/451 (<1)
  Unknown 5/512 (1) 7/451 (2)
 Missing data 15/702 (2) 20/603 (3)
Metropolitan residence — no. (%)§ 586 (83) 547 (91)
Neonatal
Female sex — no. (%) 336 (48) 314 (52)
Birth weight — g 3026.4+455.4 3012.8+490.4
Gestational age — wk 38.6+1.3 38.6+1.3
Polysubstance exposure — no. (%) 420 (60) 343 (57)
*

Plus–minus values are means ±SD. IQR denotes interquartile range.

Race or ethnic group was obtained from the electronic medical record. The category of “other” includes American Indian or Alaska Native, Native Hawaiian or other Pacific Islander, Asian, and more than one race.

Adequate prenatal care was defined as at least three visits before the start of the third trimester.

§

Metropolitan residence was determined by means of rural–urban commuting area codes.

Polysubstance exposure included exposure to opioids and an additional psychotropic agent, excluding nicotine. Additional exposures included amphetamines, barbiturates, benzodiazepines, kratom, cocaine, gabapentin, marijuana, methamphetamines, phencyclidine, and selective serotonin reuptake inhibitors.