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Myocardial O2 demand (SPTI) and supply (DPTI) with or without mechanical unloading. Modified Wigger's diagram showing progressive mechanical unloading (represented by grey dotted arrow) and uncoupling of LV pressure (LVP—red themed loops) and aortic pressure (AoP—blue themed loops), correlated with increased DPTI (grey overlay) and decreased SPTI (hashed overlay. Adapted from: (47).
