. Author manuscript; available in PMC: 2024 Oct 1.

Published in final edited form as: Alzheimers Dement. 2022 Feb 9;19(10):4498–4506. doi: 10.1002/alz.12557

Table 2.

Association of CSF biomarkers with depressive (BDI-II score) and anxiety symptoms (BAI score) in participants without dementia in the MCSA

	CU		MCI		Total sample
	Estimate (95% CI)	p-value	Estimate (95% CI)	p-value	Estimate (95% CI)	p-value
BDI-II total score
Aβ42	−0.188 (−0.333, −0.042)	0.011	−0.501 (−0.877, −0.125)	0.010	−0.244 (−0.379, −0.109)	<0.001
t-tau	−0.024 (−0.214, 0.166)	0.805	−0.033 (−0.585, 0.520)	0.907	0.006 (−0.174, 0.185)	0.952
p-tau	−0.007 (−0.188, 0.175)	0.944	−0.051 (−0.554, 0.453)	0.841	0.022 (−0.148, 0.192)	0.801
t-tau/Aβ42 ratio	0.175 (0.029, 0.321)	0.019	0.433 (0.075, 0.792)	0.018	0.242 (0.108, 0.376)	<0.001
p-tau/Aβ42 ratio	0.159 (0.024, 0.295)	0.021	0.373 (0.034, 0.713)	0.032	0.219 (0.094, 0.343)	0.001
BAI total score
Aβ42	−0.129 (−0.271, 0.013)	0.075	−0.583 (−0.998, −0.168)	0.006	−0.211 (−0.346, −0.075)	0.002
t-tau	0.004 (−0.182, 0.189)	0.970	−0.416 (−1.022, 0.189)	0.175	−0.012 (−0.191, 0.167)	0.895
p-tau	0.019 (−0.158, 0.196)	0.832	−0.369 (−0.921, 0.183)	0.187	0.009 (−0.160, 0.179)	0.914
t-tau/Aβ42 ratio	0.132 (−0.011, 0.274)	0.070	0.334 (−0.071, 0.738)	0.104	0.199 (0.065, 0.333)	0.004
p-tau/Aβ42 ratio	0.123 (−0.010, 0.255)	0.069	0.285 (−0.097, 0.667)	0.142	0.184 (0.059, 0.308)	0.004

Abbreviations: CSF, cerebrospinal fluid; MCSA, Mayo Clinic Study of Aging; CU, cognitively unimpaired persons; MCI, persons with mild cognitive impairment; CI, confidence interval; Aβ42, amyloid beta_1–42; t-tau, total tau; p-tau, phosphorylated tau; BDI-II, Beck Depression Inventory; BAI, Beck Anxiety Inventory. Linear regression models were adjusted for age, sex, education, and APOE ε4 carrier status. Significant p-values appear bold.