FIG 2.

Activity of PfFNT inhibitors on mutated PfFNT expressed in yeast. (A) PfFNT wild-type and the variants G21E and V196L were expressed in yeast, and compound activity was determined by uptake inhibition of ¹⁴C-labeled lactate. n = 3, error bars denote standard error of the mean (SEM). (B) Virtual docking of PfFNT wild-type (PDB no. 7E27) and a generated PfFNT V196L model with MMV007839, BH296, and BH267.meta. Schrödinger-induced fit docking scores (IFD) are indicated for the highest-ranked docking pose for each protein-inhibitor pair.