TABLE 3.
MIC of oxiconazole against clinical strains of drug-resistant S. aureus and Enterococcus spp.a
| Designation | S. aureus strain | Antibiotic resistance to: | Molecular detail(s) of strains | MIC of oxiconazole (mg/L) | |
|---|---|---|---|---|---|
| MSSA | ATCC 29213 | None | Type strain | 2 | |
| MRSA | NRS100 | Meth, tetra | Contains subtype I mec cassette and large variety of virulence factors | 4 | |
| NRS119 | Genta, line, meth, tri/sul | Contains subtype IV mec cassette and G2576T mutation in domain V in 23S rRNA genes | 4 | ||
| NRS129 | Chlor | mecA negative | 4 | ||
| NRS186 | Meth, levo, mero | USA 300 type CA-MRSA, PVL factor positive and contains mec type IV cassette | 4 | ||
| NRS191 | Meth, levo, mero | USA 600 type CA-MRSA, PVL factor negative and contains mec type II cassette | 4 | ||
| NRS192 | Meth, levo, mero, ery | CA-MRSA, PVL factor negative and contains mec type II cassette | 4 | ||
| NRS193 | Meth, levo, mero | CA-MRSA, PVL factor negative and contains mec type II cassette | 4 | ||
| NRS194 | Meth, mero | CA-MRSA, PVL factor positive and contains mec type V cassette | 4 | ||
| NRS198 | Meth, mero, levo | USA 100 type CA-MRSA, PVL factor negative and contains mec type II cassette | 4 | ||
| VRSA | VRS 1 | Meth, levo, van, mero, genta, spec, teico | USA 100, contains mec subtype II cassette and vanA, negative for vanB, vanC1, vanC2, vanD, vanE, PVL, and ACME | 4 | |
| VRS 4 | Meth, levo, van, mero, genta, spec, teico | USA 100, contains mec subtype II cassette and vanA, negative for vanB, vanC1, vanC2, vanD, vanE, PVL, and ACME | 4 | ||
| VRS 12 | Meth, levo, van, mero, genta, spec, teico | Data not available | 4 | ||
| Enterococcus | NR 31903 | Van, amp | Genome-sequenced strain | 4 | |
| NR 31884 | Genta | Hemolytic, cytolytic isolate; genome-sequenced strain | 16 | ||
| NR 31885 | Genta | Cytolytic isolate; genome-sequenced strain | 8 | ||
| NR 31912 | Van | Genome-sequenced strain; (GenBank accession no. AJDX00000000) | 1 | ||
a
PFGE, pulsed-field gel electrophoresis; PVL, Panton-Valentine leucocidin virulence factor; ACME, arginine catabolic mobile element; CA, community-acquired; meth, methicillin; mero, meropenem; tetra, tetracycline; van, vancomycin; teico, teicoplanin; genta, gentamicin; line, linezolid; chlor, chloramphenicol; tri/sul, trimeth/sulfa; ery, erythromycin; spec, spectinomycin; AMP, ampicillin; S, susceptible; R, resistant.